生物調節化学研究室

Original Articles

Yoshimoto Y, Tanaka M, Miyashita M, Abdel-Wahab M, M. A. Megaly A, Nakagawa Y, Miyagawa H.
A Fluorescent Compound from the Exuviae of the Scorpion, Liocheles australasiae. Journal of Natural Products, 83, 542-546 (2020), doi: 10.1021/acs.jnatprod.9b00972.

Yokoi T, Nabe T, Ishizuka C, Hayashi K, Ito-Harashima S, Yagi T, Nakagawa Y, Miyagawa H.
Transcription-inducing activity of natural and synthetic juvenile hormone agonists through the Drosophila Methoprene-tolerant protein. Pest Management Science, 76, 2316-2323 (2020), doi: 10.1002/ps.5766.

Review Articles

中川好秋
昆虫のキチン合成阻害剤の構造活性相関および分子レベルにおける作用機構　~RIセンター共同利用40念を振り返って~
京都大学環境安保健機構　RIニュース No.64, p6-p12 (2020)

中川好秋
海外留学への憧れ
京都大学農学研究科・農学部国際交流室　Newsletter No. 66 September, (2020)

義本裕介，田中柾人，宮下正弘，中川好秋，宮川恒
ヤエヤマサソリの脱皮殻に含まれる新奇蛍光物質
日本農芸化学会 2020年度トピックス集 14-15 (2020)

中川好秋
ジャーナル評価と論文の質
化学と生物　第58巻　第7号　巻頭言 379-379 (2020)

Yoshimoto Y, Tanaka M, Miyashita M, Abdel-Wahab M, M. A. Megaly A, Nakagawa Y, Miyagawa H.
Scorpions make a fluorescent compound that could help protect them from parasites
American Chemical Society Weekly PressPac

Original Articles

Juichi H, Miyashita M, Nakagawa Y, and Miyagawa H.
Isolation and characterization of the insecticidal, two-domain toxin LaIT3 from the Liocheles australasiae scorpion venom. Biosci. Biotechnol. Biochem., 83(12), 2183-2189, (2019)

Takisawa R, Kusaka H, Nishino Y, Miyashita M, Miyagawa H, Nakazaki T, and Kitajima A.
Involvement of Indole-3-Acetic Acid Metabolism in the Early Fruit Development of the Parthenocarpic Tomato Cultivar, MPK-1. J. Plant Growth Regul., 27, 1065-1075 (2019)

Uchibori-Asano M, Jouraku A, Uchiyama T, Yokoi K, Akiduki G, Suetsugu Y, Kobayashi T, Ozawa A, Minami S, Ishizuka C, Nakagawa Y, Daimon T, Shinoda T.
Genome-wide Identification of Tebufenozide Resistant Genes in the Smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae) Sci. Rep. (2019) 9:4203　doi.org/10.1038/s41598-019-40863-5

Yokoi T, Nakagawa Y, Miyagawa H.
Asymmetric synthesis of tetrahydroquinoline-type ecdysone agonists and QSAR of their binding affinity against Aedes albopictus ecdysone receptors.Pest Manag. Sci.75, 115-124 (2019)

Horoiwa S, Yokoi T, Masumoto S, Minami S, Ishizuka C, Kishikawa H, Ozaki S, Kitsuda S, Nakagawa Y, Miyagawa H.
Structure-based virtual screening for insect ecdysone receptor ligands using MM/PBSA. Bioorg. Med. Chem. , 27, 1065-1075 (2019)

Yoshimoto Y, Miyashita M, Abdel-Wahab M, Moustafa S, Nakagawa Y, Miyagawa H.
Isolation and Characterization of Insecticidal Toxins from the Venom of the North African Scorpion, Buthacus leptochelys. Toxins,11(4), 236 (2019)

Review Articles

宮川恒
農芸化学とAgricultural Chemistry
化学と生物　第57巻　第12号　巻頭言 717-717 (2019)

宮下正弘
サソリ毒に含まれる生理活性ペプチドの多様な構造ー巧みに設計されたサソリ毒素
化学と生物　第57巻　第8号　484-491 (2019)

中川好秋
満井喬先生を偲んで
日本農薬学会誌　第44巻　第2号　261-263(2019)

杉浦愛理，幌岩真理，青木孝憲，瀧本征佑，山上あゆみ，中野雄司，中川好秋，宮川恒
平成31年度論文賞対象論文の概要とその研究背景
日本農薬学会誌　第44巻　第2号　164-165 (2019)

Unsworth J, Nakagawa Y, Harris C, Kleter G.
The battle for a sustainable food supply In "Sustainable Agrochemisty" (S. Vaz Jr. Ed.). Chapter 2, Springer Nature Switzerland AG 2019, pp, 13-84 (2019)

中川好秋
日本農薬学会の設立と学会誌刊行の歴史〜JPSのPubMed収載への道のり〜
日本農薬学会誌　第44巻　第１号　1-4 (2019)

石原亨，矢吹芳教，中川好秋
インドにおける飼料作物に対する農薬の使用状況
日本農薬学会誌　第44巻　第１号　29-32 (2019)

Original Articles

Kurata K, Niinomi Y, Shimono Y, Miyashita M, and Tominaga T.
Non-target-site mechanism of glyphosate resistance in Italian ryegrass (Lolium multiflorum). Weed Biol. Manag., 18, 127-135 (2018)

Juichi H, Ando R, Ishido T, Miyashita M, Nakagawa Y, Miyagawa.
Chemical synthesis of a two-domain scorpion toxin LaIT2 and its single-domain analogs to elucidate structural factors important for insecticidal and antimicrobial activities. J. Peptide Sci., 24, e3133 (2018), doi: 10.1002/psc.3133

Watanabe B, Kirikae H, Koezuka T, Takeuchi Y, Asai T, Naito Y, Tokuoka H, Horoiwa S, Nakagawa Y, Shimizu B, Mizutani M, Hiratake J.
Synthesis and inhibitory activity of mechanism-based 4-coumaroyl-CoA ligase inhibitors. Bioorg. Med. Chem. ,26, 2466-2474 (2018)

Review Articles

中川好秋，赤松美紀
農薬の構造活性相関研究ー新規農薬の創製を目指してー "農薬の創製研究の動向ー安全で環境に優しい農薬開発の展開ー（監修：梅津憲治）"，シーエムシー出版，pp. 318-332, (2018)

中川好秋，宮川恒
藤田稔夫先生を偲んで
日本農薬学会誌　第43巻　第１号　99-100 (201８)

Nakagawa Y, Smagghe G.
Obituary: Professor Toshio Fujita. Pest Manag. Sci.,74, 263 (2018)

Nakagawa Y.
Editorial. J. Pestic. Sci.,43, 153 (2018)

Asami T, Nakagawa Y.
Preface to the Special Issue: Brief review of plant hormones and their utilization in agriculture. J. Pestic. Sci.,43, 154-158 (2018)

Patent

国際特許出願（PCT/JP2018 8083)
「植物ステロイドホルモン（ブラシノライド）様活性をもつ非ステロイド化合物の創製」発明者　中川好秋，杉浦愛理，瀧本征佑，幌岩真理，宮川恒，松尾美登理，出願人：国立大学法人京都大学（出願日：平成30年3月2日 受付番号 5180043895 国際公開番号 WO 2018/159827 A1）

Original Articles

Miyashita M, Kitanaka A, Yakio M, Yamazaki Y, Nakagawa Y, Miyagawa H.
Complete de novo sequencing of antimicrobial peptides in the venom of the scorpion Isometrus maculatus. Toxicon, 139, 1-12 (2017)

Kitanaka A, Juichi H, Nihashi Y, Miyashita M, Miyagawa H.
A facile method for preferential modification of the N-terminal amino group of peptides using triazine-based coupling reagents. Mass Spectrom. (Tokyo), 6, A0059 (2017)

Yokoi T, Nakagawa Y, Miyagawa H.
Quantitative structure-activity relationship of substituted imidazothiadiazoles for their binding against the ecdysone receptor of Sf-9 cells. Bioorganic & Medicinal Chemistry letters., 27, 5305-5309 (2017)

Abdel-Wahab M, Miyashita M, Ota Y, Juichi H, Okabe R, Moustafa S, Fouda M, Abdel-Rahman M, Saber S, Nakagawa Y.
Isolation, structural identification and biological characterization of two conopeptides from the Conus pennaceus venom. Biosci. Biotechnol. Biochem., 81, 2086-2089 (2017)

Ito-Harashima S, Matsuura M, Kawanishi M, Nakagawa Y, Yagi T.
New reporter gene assays for detecting natural and synthetic molting hormone agonists using yeasts expressing ecdysone receptors of various insects.FEBS Open Bio, 7, 995-1008 (2017)

Sugiura A, Horoiwa S, Aoki T, Takimoto S, Yamagami A, Nakano T, Nakagawa Y, Miyagawa H.
Discovery of a nonsteroidal brassinolide-like compound, NSBR1. J. Pesic. Sci., 42, 105-111 (2017)
日本農薬学会論文賞2019 受賞

Watanabe B, Yamamoto S, Yokoi T, Sugiura A, Horoiwa S, Aoki T, Miyagawa H, Nakagawa Y.
Brassinolide-like activity of castasterone analogs with varied side chains against rice lamina inclination. Bioorg. Med. Chem., , 25, 4566-4578 (2017)

Review Articles

宮下正弘
de novo Peptide Sequencingの基礎と実際
J. Mass Spectrom. Soc. Japan., 65, 231-238 (2017)

宮川　恒
農薬はどう教えられているかー教科書に登場する農薬ー
植物防疫　第71巻　第9号　571-575 (2017)

Nakagawa Y, Miyagawa H.
Obituary: Toshio Fujita, 1929-2017. J. Pesic. Sci., 42, 177-178 (2017)

中川好秋
脱皮ホルモン様活性化合物のQSAR
日本農薬学会誌　第42巻　第１号　38-43 (2017)

宮川　恒
農薬はどう教えられているか
日本農薬学会誌　第42巻　第１号　153-158 (2017)

中川好秋
藤田稔夫先生が日本薬学会功労賞を受賞されました
SAR News No32, p.1, 2017

中川好秋
藤田稔夫先生追悼
SAR News No33, pp.1-2, 2017

Original Articles

Kitanaka A, MIyashita M, Kubo A, Satoh T, Toyoda M, Miyagawa H.
N-Terminal Derivatization with Structures Having High Proton Affinity for Discrimination between Leu and Ile Residues in Peptides by High-Energy Collision-Induced Dissociation. Mass Spectrom. (Tokyo), 5, A0051 (2016).

Miyata K, Nakagawa Y, Kimura Y, Ueda K, Akamatsu M.
Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport. Biorg. Med. Chem., 24, 3184-3191 (2016).

Takimoto S, Sugiura A, Minami S, Tasaka T, Nakagawa Y, Miyagawa H.
In silico exploration for agonists/antagonists of brassinolide. Biorg. Med. Chem. Lett., 26, 1709-1714 (2016)

Kim Y, Miyashita M, Miyagawa H.
Early signaling events induced by the peptide elicitor PIP-1 necessary for acetosyringone accumulation in tobacco cells. Biosci. Biotechnol. Biochem., 80, 1054-1057 (2016).

Miyata K, Nakagawa Y, Kimura Y, Ueda K, Akamatsu M.
In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines. Tox. Appll. Pharm., 298, 40-47 (2016).

Abdel-Wahab M, Miyashita M, Kitanaka A, Juichi H, Sarhan M, Fouda M, Abdel-Rahman M, Saber S, Nakagawa Y.
Characterization of the venom of the vermivorous cone snail Conus fulgetrum. Biosci. Biotechnol. Biochem. 80, 1879-1882 (2016).

Aoki H, Ishihara A, Miyashuta M, Miyagawa H, Yatou O, Saito K.
Involvement of the Rice OsSAUR51 gene in the auxin-related field resistance mechanism against bacterial blight disease. JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY, 50,219-227 (2016).

Ishihara A, Fukami A, Matsuda Y, Nakajima H, Miyagawa H.
Accumulation of indole-3-acetic acid in rice s1 mutant leaves infected with Bipolaris oryzae. J. Phytopathology , 164,509-519 (2016).

Review Articles

宮下正弘
サソリ毒は生理活性ペプチドの宝庫
生物工学会誌　第94巻　38-41 (2016)

Nakagawa Y, Sonobe H.
Ecdysteroids. In "Handbook of Hormones-Comparative endocrinology for basic and clinical research”, http://booksite.elsevier (Eds. Takei Y, Ando H, Tsutsui K), The Japan Society for Comparative Endocrinology, e98-1-e98-14, 557-559 (2016)

Nakagawa Y, Sonobe H.
20-Hydroxyecdysone. In "Handbook of Hormones-Comparative endocrinology for basic and clinical research”, http://booksite.elsevier (Eds. Takei Y, Ando H, Tsutsui K), The Japan Society for Comparative Endocrinology, e98A-2, 560-563 (2016)

Unsworth JB, Corsi C, Van Emon JM, Farenhorst A, Hamilton DJ, Howard CJ, Hunter R, Jenkins JJ, Kleter GA, Kookana RS, Lalah JO, Leggett M, Miglioranza KSB, Miyagawa H, Peranginangin N, Rubin B, Saha B, Shakil NA
Developing global leaders for research, regulation, and stewardship of crop protection chemistry in the 21st century. J. Agric. Food Chem. , 64,52-60 (2016).

Original Articles

Bunta Watanabe, Saki Minami, Hideaki Ishida, Ryuzo Yoshioka, Yoshiaki Nakagawa, Tsuyoshi Morita, Ken’ichiro Hayashi.
Stereospecific inhibitory effects of CCG-1423 on the cellular events mediated by myocardin-related transcription factor A. PLoS One., 2015 Aug 21;10(8):e0136242. doi: 10.1371/journal.pone.0136242.

Nagao J, Miyashita M, Nakagawa Y, Miyagawa H.
Chemical synthesis of La1 isolated from the venom of the scorpion Liocheles australasiae and determination of its disulfide bonding pattern. J. Pept. Sci., 21, 636-643 (2015)

Kim Y, Miyashita M, Miyagawa H.
Photocontrol of Elicitor Activity of PIP-1 to Investigate Temporal Factors Involved in Phytoalexin Biosynthesis. J. Agric. Food Chem., 63 5894-5901 (2015)

Yokoi T, Minami S, Nakagawa Y, Miyagawa H.
Structure-activity relationship of imidazothiadiazole analogs for the binding to the ecdysone receptor of insect cells. Pest. Biochem. Physiol., 120, 40-50 (2015)

Original Articles

Kim Y, Komoda E, Miyashita M, Miyagawa H.
Continuous stimulation of the plant immune system by the peptide elicitor PIP-1 is required for phytoalexin biosynthesis in tobacco cells. J. Agric. Food Chem., 62, 5781-5788 (2014)

Ozaki S, Nakagawa Y, Shirai O, Kano K.
Substituent effect on the thermodynamic solubility of structural analogs: Relative contribution of crystal packing and hydration. J. Pharm. Sci., 103, 3524-3531 (2014)

Kamachi S, Nagao J, Miyashita M, Nakagawa Y, Miyagawa H, Tada T.
Crystallization and preliminary X-ray diffraction studies of La1 from Liocheles australasiae. Acta Cryst., F70, 915-917 (2014)

Morishita C, Minakuchi C, Yokoi T, Takimoto S, Hosoda A, Akamatsu M, Tamura H, Nakagawa Y.
cDNA cloning of ecdysone receptor (EcR) and ultraspiracle (USP) from Harmonia axyridis and Epilachna vigintioctopunctata and the evaluation of the binding affinity of ecdysone agonists to the in vitro translated EcR/USP heterodimer. J. Pestic. Sci., 39, 76-84 (2014)

Hayashi K, Watanabe B, Nakagawa Y, Minami S, Morita T.
RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling. PLoS One., 2014 Feb 18;9(2):e89016. doi: 10.1371/journal.pone.0089016.

Kitamura S, Harada T, Hiramatsu H, Shimizu R, Miyagawa H, Nakagawa Y.
Structural requirement and stereospecificity of tetrahydroquinolines as potent ecdysone agonists. Bioorg. Med. Chem. Lett., 24, 1715-1718 (2014)

Review Articles

Nishioka T, Kasama T, Kinumi T, Makabe H, Matsuda F, Miura D, Miyashita M, Nakamura T, Tanaka K, Yamamoto A.
Winners of CASMI2013: Automated Tools and Challenge Data. Mass Spectrometry, 3, S0039-S (2014)

Sabljic A, Nakagawa Y.
Biodegradation and quantitative structure-activity relationship (QSAR). In “Non-First Order Degradation and Time-Dependent Sorption of Organic Chemicals in Soil” (W. Chen, A. Sabljic, S. A. Cryer, R. S. Kookana, Eds.), ACS Symp. Ser. 1174. American Chemical Society, Washington, D.C., pp. 57-84 (2014).

Sabljic A, Nakagawa Y.
Sorption and quantitative structure-activity relationship (QSAR). In “Non-First Order Degradation and Time-Dependent Sorption of Organic Chemicals in Soil” (W. Chen, A. Sabljic, S. A. Cryer, R. S. Kookana, Eds.), ACS Symp. Ser. 1174. American Chemical Society, Washington, D.C., pp. 85-118 (2014).

中川好秋
実験技術講座　QSAR編　第4回　農薬科学におけるQSARの活用．
日本農薬学会誌39巻18-31 (2014)

Original Articles

Ishimaru K, Hirotsu N, Madoka Y, Murakami N, Hara N, Onodera H, Kashiwagi T, Ujiie K, Shimizu B, Onishi A, Miyagawa H, Katoh E.
Loss of function of the IAA-glucose hydrolase geneTGW6 enhances rice grain weight and increases yield. Nature Genetics, 45, 707-711 (2013)

Kanaoka S, Kimura Y, Fujikawa M, Nakagawa Y, Ueda K, Akamatsu M.
Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agrochemicals. J. Pestic. Sci., 38, 112-122 (2013)

Kawachi T, Miyashita M, Nakagawa Y, Miyagawa H.
Isolation and characterization of an anti-insect β-toxin from the venom of the scorpion Isometrus maculatus. Biosci. Biotechnol. Biochem., 77, 205-207 (2013)

Morou E, Emmanouel L, Pavlidi N, Zotti M, Iatrou K, Nakagawa Y, Smagghe G, Vontas J, Swevers L.
A New Dibenzoylhydrazine with Insecticidal Activity against Anopheles Mosquito Larvae. Pest Manag. Sci., 69, 827-833 (2013)

Nihashi Y, Miyashita M, Awane H, Miyagawa H.
Differential ¹⁴N/¹⁵N-Labeling of Peptides Using N-Terminal Charge Derivatization with a High-Proton Affinity for Straightforward de novo Peptide Sequencing. Mass Spectometry, 2, A0024(2013); DOI:10.5702/massspectrometry.A0024

その他

宮川　恒
農学RI年頭雑感
RI ニュース　No.57, 2-4 (2013)

宮川　恒
農薬の必要性
農業および園芸　第8巻（第1号） 1-2 (2013)

Ichiki Y, Kawachi T, Miyashita M, Nakagawa Y, Miyagawa H.
Isolation and characterization of a novel non-selective β-toxin from the venom of the scorpion Isometrus maculatus. Biosci. Biotechnol. Biochem., 76, 2089-2092 (2012)

Ogura T, Nakagawa Y, Swevers L, Smagghe G, Miyagawa H.
Quantitative evaluation of the molting hormone activity in coleopteran cells established from the Colorado potato beetle, Leptinotarsa decemlineata. Pestic. Biochem. Physiol., 104, 1-8 (2012)

Nakagawa Y, Harada T.
Advanced Screening to Identify Novel Pesticides. In “Advanced Technologies for Managing Insect Pests” (Ishaaya I, Palli RS, Horowitz R, Eds.), Springer, Dordrecht, pp. 135-163, 2012

Dinan L, Nakagawa Y, and Hormann RE.
Structure-activity relationships of ecdysteroids and non-steroidal ecdysone agonists. Adv. Insect Physiol., 43, 251-298 (2012)

Miyashita M, Matsushita K, Nakamura S, Akahane S, Nakagawa Y, Miyagawa H.
LC/MS/MS identification of 20-hydroxyecdysone in a scorpion (Liocheles australasiae) and its binding affinity to in vitro-translated molting hormone receptors. Insect Biochem. Mol. Biol., 41, 932-937 (2011)

Horita S, Matsushita N, Kawachi T, Ayabe R, Miyashita M, Miyakawa T, Nakagawa Y, Nagata K, Miyagawa H, Tanokura M.
Solution structure of a short-chain insecticidal toxin LaIT1 from the venom of scorpion Liocheles australasiae. Biochem. Biophys. Res. Comm., 411, 738-744 (2011)

Miyashita M, Oda M, Ono Y, Komoda E, Miyagawa H.
Discovery of a Small Peptide from Combinatorial Libraries That Can Activate the Plant Immune System by a Jasmonic Acid Signaling Pathway, ChemBioChem, 12, 1323-1329 (2011)

Miyashita M, Hanai Y, Awane H, Yoshikawa T, Miyagawa H.
Improving peptide fragmentation by N-terminal derivatization with high proton affinity. Rapid Commun. Mass Spectrom. 25, 1130-40 (2011)

Harada T, Nakagawa Y, Ogura T, Yamada Y, Ohe T, Miyagawa H.
Virtual screening for ligands of the insect molting hormone receptor. J. Chem. Inf. Model, 51, 296-305 (2011)

Ishihara A, Nakao T, Yuko M, Murai M, Ichimaru N, Tanaka C, Nakajima H, Wakasa K, Miyagawa H.
Probing the role of tryptophan-derived secondary metabolism in defense responses against Bipolaris oryzae infection in rice leaves by a suicide substrate of tryptophan decarboxylase. Phytochemistry, 72, 7-13 (2011)

中川好秋
脱皮の分子メカニズムとその阻害剤の構造活性相関
日本農薬学会誌 36巻, 300-303 (2011)

中川好秋
エクジステロイド受容体の構造と機能　　
脱皮と変態の生物学；昆虫と甲殻類のホルモン作用の謎を追う（園部治之・長澤寛道編）, 東海大学出版会, pp.99-121 (2011)

中川好秋
昆虫成長制御剤概論
脱皮と変態の生物学；昆虫と甲殻類のホルモン作用の謎を追う（園部治之・長澤寛道編）, 東海大学出版会, pp.147-166 (2011) Seino Y, Ogura T, Tsubota T, Shimomura M, Nakakura T, Tan A, Mita K, Shinoda T, Nakagawa Y, Shiotsuki T.
Characterization of juvenile hormone epoxide hydrolase and its telated genes in larval development of silkworm, Bombyx mori. Biosci. Biotech. Biochem., 74, 1421-1429 (2010)

Ishimoto M, Rahman SM, Hanafy MS, Khalafalla MM, El-Shemy HA, Nakamoto Y, Kita Y, Takanashi K, Matsuda F, Murano Y, Funabashi T, Miyagawa H, Wakasa K.
Evaluation of amino acid content and nutritional quality of transgenic soybean seeds with high-level tryptophan accumulation. Molecular Breeding, 25, 313-326 (2010)

Matsuda F, Ishihara A, Takanashi K, Morino K, Miyazawa H, Wakasa K, Miyagawa H.
Metabolic profiling analysis of genetically modified rice seedlings that overproduce tryptophan reveals the occurrence of its inter-tissue translocation, Plant Biotechnology, 27, 17-27 (2010)

Soin T, De Geyter E, Mosallanejad H, Iga M, Martin D, Ozaki S, Kitsuda S, Harada T, Miyagawa H, Stefanou D, Kotzia G, Efrose R, Labropoulou V, Geelen D, Iatrou K, Nakagawa Y, Janssen CR, Smagghe G, Swevers L.
Assessment of species specificity of moulting accelerating compounds in Lepidoptera: comparison of activity between Bombyx mori and Spodoptera littoralis by in vitro reporter and in vivo toxicity assays. Pest Manag. Sci., 66, 526-35 (2010)

Soin T, Swevers L, Kotzia G, Iatrou K. Janssen CR, Rouge P, Harada T, Nakagawa Y, Smagghe G.
Comparison of the activity of non-steroidal ecdysone agonists between dipteran and lepidopteran insects, using cell-based EcR reporter assays. Pest Manag. Sci., 66, 1215-29 (2010)

Miyashita M, Sakai A, Matsushita N, Hanai Y, Nakagawa Y, Miyagawa H.
Novel amphipathic linear peptide with both insect toxicity and antimicrobial activity from the venom of the scorpion Isometrus maculates. Biosci. Biotech. Biochem., 74, 364-69 (2010)

Tsurushima T, Minami Y, Miyagawa H, Nakayashiki H, Tosa Y, Mayama S.
Induction of chlorosis, ROS generation and celldeath by a toxin isolated from Pyricularia oryzae. Biosci. Biotechnol. Biochem., 74, 2220-2225 (2010) Fujita T, Nakagawa Y.
SAR and QSAR Analyses of substituted dibenzoylhydrazines for their mode of Action as ecdysone agonists. Endocrine Disruption Modeling (Devillers, J., ed.), Taylor & FrancisGroup ,Boca Raton, FL, 359-379 (2009)

Nakagawa Y, Hormann RE, Smagghe G.
SAR and QSAR studies for in vivo and in vitro activities of ecdysone agonists. Ecdysones: Structures and Functions (Smagghe, G., ed.), Springer, 475-509 (2009)

中川好秋
昆虫脱皮の分子メカニズム−新たな害虫防除手法を探る． 昆虫科学が拓く未来（藤崎憲二、西田律夫、佐久間正幸編), 京都大学出版会, pp.271-298 (2009)

宮下正弘，中川好秋
日本に生息するサソリの持つ毒素の研究． 昆虫科学が拓く未来（藤崎憲二、西田律夫、佐久間正幸編）、京都大学出版会, pp.304-306 (2009)

宮川　恒
植物の防御に関わる含窒素二次代謝成分に関する研究
日本農薬学会誌34巻127-135 (2009) Harada T, Nakagawa Y, Wadkins RW, Potter PM, Wheelock CE.
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxyesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis. Bioorg. Med. Chem., 17, 149-164 (2009)

Mizuno T, Miyashita M, Miyagawa H.
Cellular internalization of arginine-rich peptides into tobacco suspension cells: a structure-activity relationship study. J. Peptide Sci., 15, 259-263 (2009)

Matsushita N, Miyashita M, Ichiki Y, Ogura T, Sakuradani E, Nakagawa Y, Shimizu S, Miyagawa H.
Purification and cDNA Cloning of LaIT2, a Novel Insecticidal Toxin from Venom of the Scorpion Liocheles australasiae. Biosci. Biotech. Biochem., 73, 2769-2772 (2009)

Harada T, Nakagawa Y, Akamatsu M, Miyagawa H.
Evaluation of hydrogen bonds of ecdysteroids in the ligand-receptor interactions using a protein modeling system. Bioorg. Med. Chem., 17, 5868-5873 (2009)

Arai H, Watanabe B, Nakagawa Y and Miyagawa H.
Synthesis of ponasterone A derivatives with various steroid skeleton moieties and evaluation of their binding to the ecdysone receptor of Kc cells. Steroids, 73(14), 1452-1464 (2008)

Ishihara A, Hashimoto Y, Tanaka C, Dubouzet J.G., Nakao T, Matsuda F, Nishioka T, Miyagawa H and Wakasa K.
The tryptophan pathway is involved in the defense responses of rice against pathogenic infection via serotonin production. Plant J., 54(3), 481-495 (2008)

Hormann R.E., Smagghe G. and Nakagawa Y.
Multidimensional quantitative structure-activity relationships of diacylhydrazine toxicity in Spodoptera exigua, Chilo suppressalis, and Leptinotarsa decemlineata.QSAR Comb. Sci., 27 1098-1112 (2008)

Ichimaru N, Murai M, Kakutani N, Kako J, Ishihara A, Nakagawa Y, Nishioka T, Yagi T and Miyoshi H.
Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I). Biochemistry, 47(40), 10816-10826 (2008)

Mosallanejad H, Soin T, Swevers L, Iatrou K, Nakagawa Y and Smagghe G.
Non-steroidal ecdysteroid agonist chromafenozide: Gene induction activity, cell proliferation inhibition and larvicidal toxicity, Pestic. Biochem. Physiol., 92, 70-76 (2008)

Morita D, Katoh K, Harada T, Nakagawa Y, Matsunaga I, Miura T, Adachi A, Igarashi T and Sugita M.
Trans-species activation of human T cells by rhesus macaque CD1b molecules. Biochem. Biophys. Res. Commun., 377(3), 889-893 (2008)

Yamada T, Matsuda F, Kasai K, Fukuoka S, Kitamura K, Tozawa Y, Miyagawa H and Wakasa K.
Mutation of a Rice Gene Encoding a Phenylalanine Biosynthetic Enzyme Results in Accumulation of Phenylalanine and Tryptophan. Plant Cell, 20(5), 1316-1329 (2008)

Ishihara A, Hashimoto Y, Miyagawa H, Wakasa K.
Induction of serotonin accumulation by feeding of rice striped stem borer in rice leaves. Plant Signaling & Behavior, 3, 714-716 (2008)

中川好秋、宮川恒
新しい殺虫剤、21世紀の農学第3巻−植物を守る（佐久間正幸編）．京都大学学術出版会、 pp.123-150 (2008)

甲斐建次、宮川恒
植物種により異なるオーキシンの代謝経路：LC/MS/MSで明らかになった代謝の多様性、化学と生物、第46巻、 pp.152-153 (2008) Dubouzet J.G., Ishihara A, Matsuda F, Miyagawa H, Iwata H and Wakasa K.
Integrated metabolomic and transcriptomic analyses of high-tryptophan rice expressing a mutant anthranilate synthase alpha subunit. J. Exp. Bot., 58(12), 3309-3321 (2007)

Ishihara A, Matsuda F, Miyagawa H and Wakasa K.
Metabolomics for metabolically manipulated plants: effects of tryptophan overproduction. Metabolomics, 3(3), 319-334 (2007)

Fujita T and Nakagawa Y.
QSAR and mode of action studies of insecticidal ecdysone agonists. SAR QSAR Environ. Res., 18, 77-88 (2007)

Heinzle E, Matsuda F, Miyagawa H, Wakasa K and Nishioka T.
Estimation of metabolic fluxes, expression levels and metabolite dynamics of a secondary metabolic pathway in potato using label pulse-feeding experiments combined with kinetic network modelling and simulation. Plant Journal, 50, 176-187 (2007)

Kai K, Horita J, Wakasa K and Miyagawa H.
Three oxidative metabolites of indole-3-acetic acid from Arabidopsis thaliana. Phytochemistry, 68(12), 1651-1663 (2007)

Kai K, Nakamura S, Wakasa K and Miyagawa H.
Facile Preparation of Deuterium-Labeled Standards of Indole-3-Acetic Acid (IAA) and Its Metabolites to Quantitatively Analyze the Disposition of Exogenous IAA in Arabidopsis thaliana. Biosci. Biotechnol. Biochem., 71(8), 1946-1954 (2007)

Kai K, Wakasa K and Miyagawa H.
Metabolism of indole-3-acetic acid in rice: Identification and characterization of N-beta-d-glucopyranosyl indole-3-acetic acid and its conjugates. Phytochemistry, 68, 2512-2522 (2007)

Matsuda F, Wakasa K and Miyagawa H.
Metabolic flux analysis in plants using dynamic labeling technique: Application to tryptophan biosynthesis in cultured rice cells. Phytochemistry, 68(16-18), 2290-2301 (2007)

Matsushita N, Miyashita M, Sakai A, Nakagawa Y and Miyagawa H.
Purification and characterization of a novel short-chain insecticidal toxin with two disulfide bridges from the venom of the scorpion Liocheles australasiae. Toxicon, 50, 861-867 (2007)

Minakuchi C, Ogura T, Miyagawa H and Nakagawa Y.
Effects of the structures of ecdysone receptor (EcR) and ultraspiracle (USP) on the ligand-binding activity of the EcR/USP heterodimer. J. Pest. Sci., 32, 379-384 (2007)

Miyagawa H and Ueyama I.
Summary of Scientific Programs in 11th IUPAC International Congress of Pesticide Chemistry. In Pesticide Chemsitry (Ohkawa, H. Miyagawa, H. and Lee, P.W., eds.), pp.459-478, Wiley-VCH (2007)

Miyashita M, Otake Y, Oda M and Miyagawa H.
Development of a high-throughput screening method using a cell-based, lawn format assay for the identification of novel plant defense activators from combinatorial peptide libraries. Journal of Agricultural and Food Chemistry, 55(3), 806-811 (2007)

Miyashita M, Otsuki J, Hanai Y, Nakagawa Y and Miyagawa H.
Characterization of peptide components in the venom of the scorpion Liocheles australasiae (Hemiscorpiidae). Toxicon, 50, 428-437 (2007)

Nakagawa Y, Sakai A, Magata F, Ogura T, Miyashita M and Miyagawa H.
Molecular cloning of the ecdysone receptor and the retinoid X receptor from the scorpion Liocheles australasiae. Febs Journal, 274, 6191-6203 (2007)

Tamaki H, Shimada A, Ito Y, Ohya M, Takase J, Miyashita M, Miyagawa H, Nozaki H, Nakayama R and Kumagai H.
LPT1 encodes a membrane-bound O-acyltransferase involved in the acylation of lysophospholipids in the yeast Saccharomyces cerevisiae. J. Biol. Chem., 282(47), 34288-34298 (2007)

Fujita T and Nakagawa Y.
QSAR and mode of action studies of insecticidal ecdysone agonists. SAR QSAR En Environ Res., 18, 77-88 (2007)

中川好秋
脱皮ホルモン類縁体．ホルモンハンドブック新訂eBook版（日本比較内分泌学会編）．南江堂, pp.III-B-7-b (2007) Miyagawa H.
Eleventh IUPAC International Congress of Pesticide Chemistry, Kobe, Japan, 2006 - From crop protection to crop production and beyond. In Pest Management Science (Vol. 62), pp.687-689 (2006)

Minakuchi C, Suzuki J, Toda K, Akamatsu M and Nakagawa Y.
Corrigendum to ''estimation of the hydrophobicity of 2,4-diphenyl-1,3-oxazoline analogs and QSAR analysis of their ovicidal activity against Tetranychus urticae'' [Bioorg. Med. Chem. Lett., 16, 4080-4084 (2006)]. Bioorg. Med. Chem. Lett., 16, 5473 (2006)

Kawakatsu M, Yamamoto Y and Miyagawa H.
Pyranonaphthoquinone pigment from cultured lichen mycobiont of Haematomma sp. Lichenology, 5(1), 31-36 (2006)

Suzuki J, Tanji I, Ohta Y, Toda K and Nakagawa Y.
QSAR of 2,4-diphenyl-1,3-oxazolines for ovicidal activity against the two-spotted spider mite Tetranychus urticae. J. Pestic. Sci., 31, 409-416 (2006)

Minakuchi C, Suzuki J, Toda K, Akamatsu M, Nakagawa Y.
Estimation of the hydrophobicity of 2,4-diphenyl-1,3-oxazoline analogs and QSAR analysis of their ovicidal activity against Tetranychus urticae. Bioorg. Med. Chem. Lett., 16, 4080-4084 (2006)

Yamamoto S, Watanabe B, Otsuki J, Nakagawa Y, Akamatsu M and Miyagawa H.
Synthesis of 26,27-bisnorcastasterone analogs and analysis of conformation-activity relationship for brassinolide-like activity. Bioorg. Med. Chem., 14, 1761-1770 (2006).

Wheelock C.E., Nakagawa Y, Harada T, Oikawa N, Akamatsu M, Smagghe G, Stefanou D, Iatrou K and Swevers L.
High throughput screening of ecdysone agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity. Bioorg. Med. Chem., 14, 1143-1159 (2006)

Ishihara A, Asada Y, Takahashi Y, Yabe N, Komeda Y, Nishioka T, Miyagawa H and Wakasa K.
Metabolic changes in Arabidopsis thaliana expressing the feedback-resistant anthranilate synthase alpha subunit gene OASA1D. Phytochemistry, 67, 2349-2362 (2006)

Wakasa K, Hasegawa H, Nemoto H, Matsuda F, Miyazawa H, Tozawa Y, Morino K, Komatsu A, Yamada T, Terakawa T and Miyagawa H.
High-level tryptophan accumulation in seeds of transgenic rice and its limited effects on agronomic traits and seed metabolite profile. J. Exp. Bot., 57, 3069-78 (2006)

Ohnishi T, Nomura T, Watanabe B, Ohta D, Yokota T, Miyagawa H, Sakata K and Mizutani M.
Tomato cytochrome P450 CYP734A7 functions in brassinosteroid catabolism. Phytochemistry, 67, 1895-906 (2006)

Miyata K, Miyashita M, Nose R, Otake Y and Miyagawa H.
Development of a colorimetric assay for determining the amount of H2O2 generated in tobacco cells in response to elicitors and its application to study of the structure-activity relationship of flagellin-derived peptides. Biosci. Biotechnol. Biochem., 70, 2138-2144 (2006) Matsuda F, Morino K, Ano R, Kuzawa M, Wakasa K and Miyagawa H.
Metabolic flux analysis of the phenylpropanoid pathway in elicitor-treated potato tuber tissue. Plant Cell Physiol., 46, 454-446 (2005)

Minakuchi C, Nakagawa Y, Kamimura M and Miyagawa H.
Measurement of receptor-binding activity of non-steroidal ecdysone agonists using in vitro expressed receptor proteins (EcR/USP complex) of Chilo suppressalis and Drosophila melanogaster In “New Discoveries in Agrochemicals.” (J. Marshall Clark, Hideo Ohkawa, Eds.). ACS Symp. Ser., 892, American Chemical Society, Washington, D.C., pp.191-200 (2005)

Miyashita M, Shimada T, Miyagawa H and Akamatsu M.
Surface plasmon resonance-based immunoassay for 17beta-estradiol and its application to the measurement of estrogen receptor-binding activity. Anal. Bioanal. Chem., 381, 667-73 (2005)

Morino K, Matsuda F, Miyazawa H, Sukegawa A, Miyagawa H and Wakasa K.
Metabolic profiling of tryptophan-overproducing rice calli that express a feedback-insensitive a subunit of anthranilate synthase. Plant Cell Physiol., 46, 514-521 (2005)

Nakagawa Y, Takahashi K, Kishikawa H, Ogura T, Minakuchi C and Miyagawa H.
Classical and three-dimensional QSAR for the inhibition of [3H]ponasterone A binding by diacylhydrazine-type ecdysone agonists to insect Sf-9 cells. Bioorg. Med. Chem., 13, 1333-1340 (2005)

Ogura T, Nakagawa Y, Minakuchi C and Miyagawa H.
QSAR for binding affinity of substituted dibenzoylhydrazines to intact Sf-9 cells. J. Pestic. Sci., 30, 1-6 (2005) Matsuda F, K. Morino, H. Miyazawa, M. Miyashita, and H. Miyagawa
Determination of Potato Glycoalkaloids using High-pressure Liquid Chromatography-Electrospray Ionizaion/Mass Spectrometry.
Phytochem. Anal. 15; 121-124, 2004

Minakuchi, C., Y. Nakagawa, Y. Soya and H. Miyagawa
Preparation of functional ecdysteroid receptor proteins (EcR and USP) using a wheat germ cell-free protein synthesis system.
J Pestic Sci 29; 189-194, 2004

Miyashita, M., T. Shimada, S. Nakagami, N. Kurihara; H. Miyagawa and Akamatsu, M
Enantioselective recognition of mono-demethylated methoxychlor metabolites by the estrogen receptor.
Chemosphere 54; 1273-1276, 2004

Nishiwaki, H., K. Sato, Y. Nakagawa, M. Miyashita, and H. Miyagawa
Metabolism of imidacloprid in houseflies.
J Pestic Sci 29; 110-116, 2004

Okazaki Y., T. Isobe, Y. Iwata, T. Matsukawa, F. Matsuda, H. Miyagawa, A. Ishihara, T. Nishioka and H. Iwamura
Metabolism of avenanthramide phytoalexins in oats.
Plant J 39; 560-572, 2004

Swevers, L., L. Kravariti, S. Ciolfi, M. Xenou-Kokoletsi, N. Ragoussis, G. Smagghe, Y. Nakagawa, B. Mazomenos, and I. Kostas
A cell-based high-throughput screening system for detecting ecdysteroid agonists and antagonists in plant extracts and libraries of synthetic compounds.
FASEB J 18; 134-136, 2004

Watanabe, B., S. Yamamoto, K. Sasaki, Y. Nakagawa, and H. Miyagawa
A simple synthesis of 6-deoxoteasterone and its 20-epimer.
Tetrahedron Lett 45; 2767-2769, 2004

Watanabe, B., Y. Nakagawa, T. Ogura and H. Miyagawa
Stereoselective synthesis of (22R)- and (22S)-castasterone/ponasterone A hybrid compounds and evaluation of their molting hormone activity. Steroids 69; 483-493, 2004

Uesusuki, S., B. Watanabe, S. Yamamoto, J. Otsuki, Y. Nakagawa and H. Miyagawa
Synthesis of Brassinosteroids of Varying Acyl Side Chains and Evaluation of Their Brassinolide-like Activity.
Biosci Biotech Biochem 68; 1097-1105, 2004

Kawakatsu, M., H. Miyagawa and N. Hamada
Variations in the concentrations of chemical substances produced by cultured lichen mycobionts.
Lichenology, 2 (1); 11-15, 2003

Kiriyama, K., H. Nishiwaki, Y. Nakagawa and K. Nishimura
Insecticidal activity and nicotinic acetylcholine receptor binding of dinotefuran and its analogues in the housefly, Musca domestica.
Pest Manag Sci, 59; 1093-1100, 2003

Matsuda, F., K. Morino, M. Miyashita and H. Miyagawa
Metabolic flux analysis of the phenylpropanoid pathway in wound-healing potato tuber tissue using stable isotope-labeled tracer and LC-MS spectroscopy.
Plant Cell Physiol, 44(5);, 510-517, 2003

Minakuchi, C., Y. Nakagawa, M. Kiuchi, A. Seino, S. Tomita and M. Kamimura
Molecular cloning and expression analysis of ultraspiracle (USP) from the rice stem borer Chilo suppressalis.
Insect Biochem Mol Biol, 33; 41-49, 2003

Minakuchi, C, Y. Nakagawa and H. Miyagawa
Validity analysis of a receptor binding assay for ecdysone agonists using cultured intact insect cells.
J Pestic Sci, 28, 51-53, 2003

Minakuchi, C., Y. Nakagawa, M. Kamimura and H. Miyagawa
Binding affinity of non-steroidal ecdysone agonists against the ecdysone receptor complex (EcR/USP) determines the strength of their molting hormonal activity.
Eur J Biochem, 270; 4095-4104, 2003

Miyashita, M., T. Nakamori, H. Miyagawa, M. Akamatsu, T. Ueno
Inhibitory activity of analogs of AM-Toxin, a host-specific phytotoxin from the Alternaria alternata apple pathotype, on photosynthetic O2 evolution in apple leaves.
Biosci Biotech Biochem, 67 (3); 635-638, 2003

Nishiwaki, H.,Y. Nakagawa, M. Kuwamura, K. Sato, M. Akamatsu, K. Matsuda, K. Komai, H. Miyagawa
Correlations of the electrophysiological activity of neonicotinoids with their binding and insecticidal activities.
Pest Manag Sci, 59; 1023-1030, 2003

Watanabe, B., Y. Nakagawa, and H. Miyagawa
Synthesis of a castasterone/ponasterone hybrid compound and evaluation of its molting hormone-like activity.
J Pestic Sci, 28; 188-193, 2003

Wheelock, C. E., Y. Nakagawa, M. Akamatsu and B. D. Hammock
Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors.
Bioorg Med Chem, 11; 5101-5116, 2003

Ishihara, A., H. Miyagawa
Development of Agrochemicals in the Next Generation -new nanotechnologies in discovery and invention, H. Abe, et al., Editors.
Soft Science Inc.: Tokyo. p. 2-14, 2003

Miyashita, M.
Instrument for radiation measurement in life sciences (4). IV. Accelerator mass spectrometry in tracer studies ? Applications to biochemical studies-.
Radioisotopes, 52; 308-314, 2003

Nakagawa, Y., C. Minakuchi
Growth regulators: Insecticides in the Next Generation -new nanotechnologies in discovery and invention, H. Abe, et al., Editors.
Soft Science Inc.: Tokyo. pp.119-133, 2003

Nakagawa, Y.
Molting hormone in “Nougeikagaku no jiten,” A. Suzuki, S. Arai, Editors.
Asakura, pp168-171, 2003

Miyagawa, H., Y. Nakagawa, F. Malcolm, H. Inami, M. Suzuki
Main Topic 4-Formulation and application: Methodology, performance, safety.
J. Pestic. Sci. 28; 142-148, 2003

Miyashita, M, H. Nishiwaki
Topic A-3. Mode of Action.
J. Pestic. Sci. 28; 506-509, 2003

Wakasa, K., H. Miyagawa
Regulation of the metabolism in tryptophan biosynthetic process and its utilization.
Kagaku to Kogyo, 54; 494-499, 2003